MUTATIONAL ACTIVATION OF N-RAS-12 GENE IS ABSENT IN PEDIATRIC OSTEOSARCOMA
نویسندگان
چکیده
منابع مشابه
Mutational activation of ras genes is absent in pediatric osteosarcoma.
Activation of ras oncogenes is found in human cancers; overall it is observed in 15% of all neoplasms. The purpose of this study was to assess the extent of involvement of ras oncogenes in osteosarcoma. Tumor samples from a series of 49 pediatric patients diagnosed with osteosarcoma and treated at our institution were evaluated. Paraffin-embedded tumor samples from diagnostic biopsies, from tum...
متن کاملMutational Activation of N- and K-ras Oncogenes
The frequency of Nand K-ras oncogene mutations was investigated in plasma cell dyscrasias. Genomic DNAs from 128 patients were selected for this study: 30 monoclonal gammopathies of undetermined significance, 8 solitary plasmacytomas, 77 multiple myelomas (MM), and 13 plasma cell leukemias (PCL). A two-step experimental approach was devised. All samples were screened for mutations by single-str...
متن کاملdyscrasias Mutational activation of N - and K - ras oncogenes in plasma cell
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متن کاملMutational Activation of N - and K - ras Oncogenes in Plasma Cell Dyscrasias
The frequency of Nand K-ras oncogene mutations was investigated in plasma cell dyscrasias. Genomic DNAs from 128 patients were selected for this study: 30 monoclonal gammopathies of undetermined significance, 8 solitary plasmacytomas, 77 multiple myelomas (MM), and 13 plasma cell leukemias (PCL). A two-step experimental approach was devised. All samples were screened for mutations by single-str...
متن کاملMutational activation of k-ras oncogene in human breast-tumors.
ras genes are thought to play an important role in human cancer since they have been found to be activated frequently in several types of human tumors. From preliminary studies it has been found however, that ras mutations are extremely rare in breast tumors and therefore it was of interest to examine the frequency of such mutations. In this study we examined 65 cases of primary breast carcinom...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1994
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199402000-00084